This describes how well creatine mixes and is absorbed. Below is a list of the common creatine forms and their relative solubility score (the higher the score, the greater the solubility). As you will see, some forms of creatine such as Creatine HCL have a much greater solubility, which is why a much lower dose is required. In this context cell permeability describes how well creatine crosses the intestinal barrier. Some forms of creatine have a poor permeability, meaning most of that which is ingested is not actually absorbed, thus resulting in it being excreted in the urine. Creatine HCL has one of the highest absorption rates out of all the creatine forms currently available on the market. It is also important to note the key relationship between creatine and water. Certain sources of creatine require a large amount of water, which is one of the reasons why certain individuals experience digestive issues and extracellular water retention (outside the cell) when taking it.
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